Variable Requirements for DNA-Binding Proteins at Polycomb-Dependent Repressive Regions in Human HOX Clusters
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چکیده
منابع مشابه
S05-01. Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci
S05-01 Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci Ragnhild Eskeland, Duncan Sproul, Graeme Grimes, Shelagh Boyle, Martin Lieb, Clemence Kress, Nick Gilbert, Helle F. Jorgensen, Amanda G. Fisher, Arthur I. Skoultchi, Anton Wutz, Wendy A. Bickmore 1 University of Edinburgh, Edinburgh, United Kingdom 2 Research Institute of Molecular Pathology, V...
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In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of the two Hox complexes can interact within nuclear PcG bodies in tissues where they are corepressed....
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Early in Drosophila embryogenesis, transcriptional repressors encoded by Gap genes prevent the expression of particular combinations of Hox genes in each segment. During subsequent development, those Hox genes that were initially repressed in each segment remain off in all the descendent cells, even though the Gap repressors are no longer present. This phenomenon of heritable silencing depends ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2013
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00275-13